33 jobs for “Protein Engineer”
Alloy Therapeutics UK Ltd Cambridge £45,000 – £50,000 pa
Design and build large-scale synthetic gene loci and transgenic platforms for antibody discovery, using CRISPR/Cas9, RMCE and site-specific integrases. Hands-on molecular biology including PCR, NGS, plasmid construction and flow-cytometric immunophenotyping, within a small multidisciplinary team working from dry-lab design to wet-lab validation.
CureAge Therapeutics London
Lead the computationally guided design of a lipid nanoparticle delivery platform, applying chemical and biophysical principles to optimise LNP composition and formulation. Use AI-enabled chemistry, cheminformatics, predictive models and molecular modelling to prioritise formulation components, working closely with the experimental team and founding team in a small start-up.
Ellison Institute of Technology Oxford £40,000 pa
Postdoctoral role in the Liu Lab for Synthetic Evolution, designing and troubleshooting experiments, analysing complex data with computational and statistical tools, and publishing high-quality research. The lab invented OrthoRep for continuous accelerated gene evolution, with projects spanning antibody sequence-affinity datasets, enzyme sequence-function maps, and de novo gene function emergence. Involves mentoring junior researchers and collaborating across multidisciplinary teams.
ISR Recruitment Oxford £520 – £532 pd
Lead a laboratory-based immunology team, designing in vitro pharmacology assays and coordinating in vivo efficacy studies with CROs to advance biologic therapies for autoimmune diseases. Involves target identification, ex vivo profiling, and cross-functional work with protein engineering, biomarkers and translational medicine, plus IND documentation and publications.
Evotec Abingdon
Owns Evotec's in silico therapeutics design capability, uniting computational chemistry, generative and modality design (small molecules, peptides, protein engineering, degraders, molecular glues) and predictive ADMET/safety under one mandate. A newly created unit within the In Silico & AI group with an explicit build mandate: set technical vision, grow a multi-site team, and industrialise repeatable, benchmarked methods across partner programmes.
Gilead Sciences Oxford
Lead a team of scientists developing novel biologic therapies for autoimmune disease, overseeing in vitro and in vivo pharmacology studies for lead and early discovery programs. Collaborate across immunology, protein engineering, translational medicine and biomarkers to deliver data packages for progression to development, while mentoring staff and contributing to INDs and patents.
University of East Anglia Norwich £21,805 pa
A four-year PhD project using engineering biology to develop bacterial and human ferritin nanocages for encapsulating small molecules, peptides and proteins, with applications in biocatalysis and therapeutics. The work spans protein purification, bioanalytical methods, spectroscopy, mass spectrometry and microscopy, targeting enzymes such as hydrogenase and targeted molecular delivery. Based in the Le Brun lab at UEA's School of Chemistry, Pharmacy and Pharmacology.
Ellison Institute of Technology Oxford
Builds and leads a molecular biology and synthetic biology function within a plant science institute, setting technical strategy for high-throughput assays, sequencing-based readouts, CRISPR guide design and multiplex editing. Acts as a responsive core facility, coaching scientists on experimental design and integrating with bioinformatics, tissue culture and phenotyping teams. Combines deep technical direction with people leadership rather than routine bench work.
University of Exeter Exeter £21,805 pa
An interdisciplinary PhD studentship combining computational genomics at Exeter with stem-cell biology and CRISPR editing at Cambridge. The student will analyse whole-genome sequencing data from large multi-ancestry cohorts, integrate genetic signals with epigenetic maps and AI tools like AlphaGenome, and build iPSC-derived visceral and subcutaneous adipocyte models to functionally test prioritised regulatory variants.
University of Sussex Brighton £38,784 – £46,049 pa
Investigates how phosphorylation regulates RNA polymerase II transcription, RNA processing and gene expression, combining biochemistry, structural biology, cell biology and functional genomics. The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, transcriptome analyses and in vitro transcription reconstitution, with scope to develop independent ideas within a collaborative group.
Basecamp Research London
Owns the peptide and protein platform as a commercial product, spanning market and competitive intelligence, target product profiles, roadmap and packaging decisions, and go-to-market positioning. Sits between model, data and science teams and business development, and is accountable for partner engagement and revenue generation. Requires deep peptide therapeutics and licensing deal expertise.
Lila Sciences London US$268,000 – US$384,000 pa
Conducts original computational biology research for AI safety, investigating how LLMs, specialised biological models, agents and automated laboratories combine to change what is biologically feasible. Spans protein and nucleic-acid design, cellular systems and biological delivery, translating risk judgments into dual-use policy boundaries, evaluation priorities and mitigation requirements alongside threat modellers and red-teamers.
CSL Maidenhead
This role involves leading the R&D Resource and Schedule Management capabilities, defining the mission, governance, and operating model. Responsibilities include capacity and demand management, scenario planning, and stakeholder engagement to ensure alignment with organizational goals and portfolio priorities.
Evotec Abingdon
Leads Evotec's consolidated AI Accelerator, owning machine learning, generative and agentic AI, and therapeutic hypothesis groups. Sets the AI vision and roadmap, makes build/buy/partner decisions for the AI stack, and turns proprietary multi-omics and experimental data into predictive models and reusable IP. Acts as the senior external technical voice for AI in drug discovery.
Imperial College London London £48,246 – £58,318 pa
Supports the production and characterisation of recombinant proteins for molecular glue discovery, focusing on expression, purification and characterisation using mammalian cell systems. Contributes to biochemical or biophysical assay development and helps run the laboratory day to day, including equipment upkeep, consumables and waste disposal, within a multidisciplinary chemical biology and proteomics team.
Sartorius Glasgow
Performs laboratory techniques under GMP conditions, including cell-based assays, ELISAs and protein characterisation, to test biological products such as monoclonal antibodies, cell and gene therapies and vaccines. Also manages stock and reagents, maintains traceability records, and prepares controlled documentation like SOPs and risk assessments within a nine-person team.
Nexus Life Sciences Belfast £50,000 – £60,000 pa
Leads a Clinical Method Development and Validation team, overseeing bioanalytical method delivery for a New Product Development programme. Provides technical leadership in a GLP-compliant lab, acting as expert in extraction techniques and optimising HPLC, UPLC and LCMSMS systems while mentoring the team.
