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Senior Scientist - DMPK

SRG
Cambridge, United Kingdom
3 weeks ago
£41,000 – £48,800 pa
Applications closed

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Salary

£41,000 – £48,800 pa

Job Type
Permanent
Work Pattern
Full-time
Work Location
On-site
Seniority
Senior
Education
Phd
Posted
30 Apr 2026 (3 weeks ago)
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Senior Scientist (DMPK)
12-month FTC
Cambridge
A leading biotech organisation is seeking a Senior Scientist with DMPK expertise to support oncology-focused discovery programs. You will develop fit-for-purpose DMPK strategies, generate and interpret ADME/PK data, and work closely with internal project teams and external CRO partners to drive decision-making across project stages.
Key Responsibilities

  • Develop and evolve an appropriate DMPK screening cascade aligned to project stage and objectives.
  • Design, execute and interpret in vitro ADME assays, communicating results clearly to project team members.
  • Oversee CRO activities including compound submissions, experiment tracking, and timely communication of data updates.
  • Prepare and maintain slide decks and documentation summarising CRO outputs and project progress; manage purchase orders and invoicing related to CRO work.
  • Maintain accurate, complete and up-to-date electronic laboratory notebooks in line with internal standards.
  • Perform LC-MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting.

Key Requirements

  • PhD or BSc/MSc with relevant experience in a life sciences discipline, plus industrial drug discovery experience.
  • Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
  • Experience using Phoenix WinNonlin.
  • Knowledge and prior experience of metabolite identification.
  • Strong time management, excellent written and verbal communication skills, and the ability to build effective relationships with internal and external partners.
  • Experience advancing discovery programs from Lead Optimisation (LO) through candidate selection.
  • Knowledge of PK-PD and/or PBPK modelling and human dose prediction.
  • Practical experience in bioanalysis by LC-MS/MS.
  • Experience with MassLynx and/or UNIFI.

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.

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