Scientist - Cell Line Engineering

A leading biopharmaceutical company is seeking an experienced Scientist to join their Antibody Cell Line Sciences team. This group sits within the Antibody and Novel Therapeutics function and plays a key role in developing engineered mammalian cell lines that support the manufacture of innovative therapeutic antibodies and complex biologics.

This is a hands-on laboratory role focused on host cell line development, cell line engineering, and optimisation of stable mammalian expression systems for antibody production.

Key Responsibilities

• Establish and develop a toolbox of host cell lines suitable for manufacturing, applying strong laboratory-based scientific expertise
  
  
• Ensure host systems can express a diverse range of molecule types and meet GMP manufacturing requirements, supported by robust documentation
  
  
• Engineer and generate stable mammalian cell lines for antibody and novel antibody-format expression
  
  
• Apply a variety of host engineering and genome editing techniques to develop improved expression systems
  
  
• Analyse expression and engineering data to draw clear conclusions and inform next steps
  
  
• Work closely with molecular biology and engineering teams to drive technical progress
  
  
• Communicate progress effectively across multidisciplinary teams, highlighting risks, issues, and potential opportunities
  
  
• Maintain accurate documentation and records in line with scientific and regulatory standards
  
  Skills & Experience
  
  
• Minimum BSc in a relevant life sciences discipline
  
  
• Experience generating stable mammalian cell lines for protein or antibody expression
  
  
• Strong cell culture expertise, ideally within a biopharmaceutical environment
  
  
• Experience with genome engineering technologies, such as CRISPR-based cell engineering
  
  
• Competence in key molecular biology techniques, including ddPCR, cloning, and plasmid construction
  
  
• Hands-on experience with flow cytometry / FACS and single-cell cloning systems
  
  The role is offered on an initial 12 month contract with realistic potential for extension.
  
  This is an excellent opportunity to join a collaborative scientific team contributing directly to the development and manufacture of next-generation biologics.
  
  VRS9388SE