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PBPK Manager

RBW Consulting
Leeds, England
10 months ago
Applications closed

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Senior Scientist - DMPK

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DMPK Lead (PBPK Specialist), London

Isomorphic Labs United Kingdom
Hybrid
Posted
20 Jul 2025 (10 months ago)
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This position is responsible for leading and managing a small team of Computational Scientists, supporting the Pharmaceutical Development team with a focus on PBPK/PBBM modelling and simulation. This position can offer the opportunity to work on a unique proprietary modelling system which is accelerating clinical drug development.


ROLE OVERVIEW

  • Provide scientific and technical leadership and management to a team of Computational Scientists in PBPK
  • Lead the execution of client and internal research and development projects in the field of computational pharmaceutics
  • To be the recognised point of contact for problem solving in the field of PBPK
  • Author and review computational reports for scientific and technical accuracy and to review reports from other teams
  • Present results to internal and external stakeholders, including clear communication of technical challenges, in a solution-oriented manner



EDUCATION, EXPERIENCE & RELEVANT SKILLS EDUCATION & QUALIFICATION

  • PhD in related discipline with track record of implementing PBPK models in drug development
  • Proven experience in software such as GastroPlus, Simcyp, MATLAB or Python to develop and utilise PBBM/PBPK models
  • Drug product development using modelling methodologies such as PBPK/PBBM
  • Drug product regulation and approval using modelling and simulation tools (i.e. interactions with regulators and authoring of regulatory documents)
  • Proven team management experience and working with various stakeholders at different levels across multiple departments

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