Ophthalmology Bioassay Senior Scientist
Nottingham | On-site
We are seeking anOphthalmology Bioassay Senior Scientist to join a growing, innovative CRO environment focused on developingnext-generation human-relevant disease models.
This role sits at the forefront of moving drug discovery away from traditional animal models, with a strong emphasis onadvanced in vitro systems, includingiPSC-derived models and 3D organoids for ocular diseases.
You will play a key role inbuilding and developing capability in ophthalmology, contributing to both project delivery and the longer-term growth of this area of the business. This is an excellent opportunity for someone who enjoys combininghands-on lab work, scientific innovation, and commercial impact.
Responsibilities:
Ocular Model Development
- Develop and optimisehuman-relevant ocular disease models
- Design and implementiPSC-derived systems, including retinal and epithelial models
- Contribute to the development ofcomplex 3D organoid and co-culture systems
Assay Development & Delivery
- Design and executebioassays relevant to ocular disease, including:
- Imaging and fluorescence-based assays
- Immunoassays
- Functional and translational assays
- Analyse and interpret experimental data and present findings clearly to stakeholders
Molecular & Cell Biology
- Apply molecular biology techniques including:
- Gene knockdown approaches (e.g. siRNA, shRNA)
- Work with primary cells, cell lines, and stem-cell derived models
- Support development of increasinglycomplex and physiologically relevant systems
Project Delivery & Growth
- Support delivery of CRO projects across drug discovery programmes
- Troubleshoot experimental challenges and drive continuous improvement
- Contribute tobuilding and scaling ophthalmology capability, including future team growth
- Engage with clients and support scientific discussions where required
About You
You are ascientist with strong hands-on experience in advanced cellular models, particularly within ophthalmology or closely related disease areas.
You'll bring:
- Experience working withiPSC-derived systems and/or 3D organoid models (critical)
- Strong laboratory experience acrossbioassays, imaging, and molecular biology techniques
- Experience working withocular models or strong transferable cell biology experience
- A proactive, problem-solving mindset with the ability to work independently
Desirable (but not essential):
- PhD in Ophthalmology, Cell Biology, Stem Cell Biology, or a related discipline
- Experience in aCRO or fast-paced applied research environment
- Exposure to replacing or reducinganimal models with human-relevant systems
- Interest in helping build or grow a new scientific capability or team
If you're excited byorganoids, stem cell models, and reducing reliance on animal testing, this role will give you the platform to make a real impact.
Apply now by attaching your CV in Word, or contact Paige Keenan for further information about this new role:
Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.
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