Director, Project Toxicologist – Oncology Targeted Delivery (OTD) Safety Science
Location: Cambridge, UK
Salary: Competitive
At AstraZeneca, our bold ambition is nothing less than to eliminate cancer as a cause of death. Our pioneering pipeline of oncology medicines reflects this mission, and our Oncology Targeted Delivery (OTD) Safety team plays a critical role in accelerating transformative therapies to patients.
We are seeking a highly motivated and passionate Director, Project Toxicologist to join our OTD Safety group. This role focuses on novel targeted oncology therapies, including Radio Conjugates, Antibody Drug Conjugates (ADCs), and Small Molecules. While experience with Radio Conjugates is particularly valued, candidates with other modality expertise are encouraged to apply.
You will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology, driving innovative safety strategies, and accelerating drug development. Your expertise will inform candidate selection, guide regulatory strategy, and help define the future of oncology safety science.
Accountabilties:
Lead regulatory and investigative toxicology study design, developing strategies to predict, assess, and mitigate target- and modality-related safety risks.
Apply your toxicology expertise to predict clinical safety risks and support data-driven decisions across discovery and development programs.
Innovate at the intersection of regulatory toxicology and cutting-edge science, leveraging in vitro, in silico, in vivo, and emerging technologies like organ-on-chip, imaging, and omics.
Communicate integrated risk assessments to governance bodies and contribute to regulatory submissions.
Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
Provide strategic toxicology input for in-licensing evaluations and external collaborations.
Drive Oncology Safety science through internal and external collaborations, publications, and thought leadership.
Education/Experience Requirements
PhD and/or DABT in Toxicology, Pharmacology, Oncology, or related fields with a strong scientific track record.
Strong prior experience in Project Toxicology, Investigative Toxicology, or related safety-focused roles in pharma, biotech, or CRO environments.
Or an advanced university degree accompanied by at least 10 years of relevant professional experiencepreferred, additional work experience in pharma industry in lieu of degree can be considered (ie. BSc with 15 yrs of experience). Minimum BSc degree with additional work experience in pharma industry required.
Deep understanding of oncology drug discovery and development, with proven ability to deliver toxicology programs supporting IND filings.
Expertise in Radio Conjugates or ADCs preferred, with familiarity in small molecule oncology therapeutics.
Skilled in using in vitro, in silico, and in vivo tools to predict clinical safety risks.
Collaborative, problem-solving mindset with the ability to coordinate across multiple projects and geographies.
Strong communication, interpersonal, and influencing skills to inform decisions across scientific and regulatory teams.
Commitment to inclusion, diversity, and team development, supporting AstraZeneca’s Great Place to Work objectives.
Why Join AstraZeneca?
AstraZeneca is where science meets data to develop bold solutions that make a tangible difference. We challenge the status quo by digging deep into data using cutting-edge methodologies to drive scientific breakthroughs. Our high-exposure roles allow us to shape deliverables while embracing global opportunities across all Therapy Areas. With a restless need for improvement, we foster an inspiring learning environment where every setback is an opportunity for growth. We combine specialist knowledge with curiosity, always searching for better ways to achieve the best results. Our dedication ensures that we put patients first while expanding our knowledge through collaboration across functions.
So, what’s next?
Complete your application before the below closing date 10th May 2026
Where can I find out more?
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
If you are ready to make a meaningful difference in cancer treatment, we want you on our team.
Apply today and help us transform the future of oncology!
Date Posted
23-Apr-2026
Closing Date
10-May-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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