Biotechnology Jobs in Oxford

• Oxford
• On-site
• Director · manages people

Lead the DMPK team at Vertex's Oxford site, shaping strategy and operations while sitting on both the Global DMPK and Oxford Site leadership teams. The role directs ADME science across discovery and development programmes, partners with Medicinal Chemistry, Biology, Preclinical Safety and Clinical Pharmacology, and oversees regulatory documentation such as INDs and marketing applications. It combines deep small-molecule DMPK expertise with hiring, mentoring and resource planning.

• Oxford
• On-site
• £40,178 – £48,700 pa
• Entry level
• Contract

Conducts research characterising crosslinked proteins and lipids under a Wellcome Trust-funded grant, using proteome and lipidome methods including sample preparation, LCMS and data analysis. Manages project administration, guides junior researchers and students, and contributes to reports, publications and external seminars.

LC-MS · nanoLC-MS

• Oxford
• On-site
• £36,360 – £42,434 pa
• Entry level
• Contract

Supports an experimental programme building predictive models of cells, maintaining mammalian cell systems and running workflows such as endogenous protein tagging, CRISPR perturbation, optical pooled screening, live-cell imaging and proteomics. Works with computational and experimental researchers, generating engineered cell models and analysing data within a collaborative lab.

CRISPR · Flow Cytometry · Immunoblotting +4

• London
• Hybrid
• Mid-level
• Permanent

Owns the transition from discovery to delivery on Mystra, a scientific data platform, breaking strategic initiatives into well-scoped epics and features. Works with scientific SMEs, data services, engineering and design to ensure requirements are scientifically valid and technically sound, running kick-offs and bi-weekly check-ins. Requires fluency with genomic data such as GWAS papers, p-values and effect sizes.

Mystra

• Oxford
• Hybrid
• Lead
• Permanent

You will apply DMPK expertise within multi-disciplinary project teams to solve drug discovery challenges and deliver high-quality candidate molecules into development. The role sits in a biotech using native mass spectrometry and custom chemistry against membrane proteins and intracellular complexes, working in state-of-the-art laboratories in Oxford.

OdyssION

• London
• Hybrid
• Lead

Lead complex oncology projects, designing and interpreting scientific and clinical strategies while guiding cross-functional teams on technical and regulatory matters. The role combines hands-on project leadership with mentoring colleagues and driving new methodologies, in a hybrid setup spanning London and Upper Providence.

• USA - Pennsylvania - Upper Providence
• Hybrid
• Lead

Lead complex oncology projects, designing and interpreting scientific and clinical strategies while collaborating with cross-functional teams and external partners. Provide expert guidance on scientific, technical and regulatory matters, drive innovation in methodologies, and mentor colleagues. Hybrid role split between London and Upper Providence, Pennsylvania.

• Oxford
• Hybrid
• Entry level
• Internship

Embedded within multidisciplinary research teams at a fast-paced Oxfordshire site, contributing to drug discovery from target validation through small molecule discovery and optimisation. The placement offers hands-on laboratory work, disease biology exposure and development of practical scientific skills alongside other students.

• Abingdon
• On-site
• Entry level
• Permanent · Shift work

Operate pilot plant reactors and ancillary equipment in a GMP-regulated large-scale chemical production environment, running multiple syntheses, some never previously scaled. Duties include routine maintenance and reconfiguration of reaction vessels, environmental monitoring, accurate batch documentation, and shift handovers. The role follows a rotating 12-hour day and night shift pattern averaging 42 hours per week.

Microsoft Office

• Manchester
• £38,448 – £46,970 pa
• Entry level
• Contract

Lead mass spectrometry-based proteomics within a Wellcome Discovery Award consortium studying microbial competition and Type VI Secretion Systems. Design and run DIA proteomics experiments, maintain timsTOF and LC instrumentation, and apply R-based analysis pipelines, publishing findings as lead or co-author.

timsTOF HT · timsTOF Ultra AIP · Liquid Chromatography +1

• Oxford
• On-site
• Senior

Sole-contributor scientist role developing and executing biochemical and molecular biology assays for PK/PD analysis, spanning genomic DNA/RNA isolation, qPCR, ddPCR, RNA sequencing, MSD, ELISA and immunoblotting. Works within Moderna's Clinical Bioanalytical team at Harwell, Oxfordshire, ensuring GcLP-compliant assay qualification and validation, troubleshooting with external CRO partners, and building internal and external mRNA-based bioanalytical capability.

MSD · LIMS · eLNB +1

• Maidenhead
• Hybrid
• Mid-level
• Temporary

Monitoring investigator sites across the North of England for a routine post-market surveillance study within a dedicated FSP model. Involves on-site and remote monitoring, building relationships with investigators, and ensuring patient safety, data quality and regulatory compliance, with travel to Oxford at least monthly plus on-site onboarding and training.

• Didcot
• On-site
• Lead · manages people

Lead a team of software engineers delivering next-generation Raman spectroscopy software from the Laser Spectroscopy Center of Excellence in Oxford (Harwell). The role owns R&D operations across the software product lifecycle, solving engineering challenges and integrating hardware and software with global partners, using modern architectures such as containerisation, Kubernetes, microservices and cloud deployment.

Kubernetes · Linux · Microsoft

• Oxford
• On-site
• £40,000 pa
• Senior
• Permanent

Develops and optimises LC-MS workflows for low-input and single-cell proteomics and/or metabolomics, supporting researchers across the institute with experiment design, method development, data acquisition and interpretation. Works closely with bioinformatics, scientific computing and AI/ML teams, and helps build SOPs and training material for single-cell MS capability.

LC-MS · Flow Cytometry · Sequencing +5

• Oxford
• On-site
• £40,000 pa
• Entry level
• Permanent

Postdoctoral role in the Liu Lab for Synthetic Evolution, designing and troubleshooting experiments, analysing complex data with computational and statistical tools, and publishing high-quality research. The lab invented OrthoRep for continuous accelerated gene evolution, with projects spanning antibody sequence-affinity datasets, enzyme sequence-function maps, and de novo gene function emergence. Involves mentoring junior researchers and collaborating across multidisciplinary teams.

OrthoRep