Jobs in Cambridge

Director of Nonclinical Safety, Cambridge, MA

Lead the development and execution of nonclinical safety strategies for small molecule drug candidates in oncology and non-oncology programs, integrating AI-driven predictive models with traditional toxicology. Build and scale the nonclinical safety function within an AI-first drug discovery environment, ensuring high-quality data feedback to refine computational models. Collaborate across preclinical, clinical, and regulatory teams to advance compounds through IND and NDA/MAA-enabling studies.

Isomorphic Labs Cambridge, United Kingdom

Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

This role involves designing and executing biological screening cascades to validate computational predictions in drug discovery. The scientist will lead biophysical, biochemical, and cellular assay development, collaborate with CROs, and bridge AI-driven insights with experimental validation across oncology and immunology programs. Close collaboration with medicinal chemistry, structural biology, and machine learning teams ensures data informs rational drug design.

Isomorphic Labs England

Hybrid Permanent

RTSM Project Manager (Randomisation and Trial Supply Management)

The RTSM Project Manager is responsible for managing clinical studies within the RAMOS IRT system, ensuring data integrity, and driving continuous improvements. The role involves configuring complex IRT study designs, leading interactions with internal and external stakeholders, and providing technical support for outsourced IRT studies.

GSK

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology and modelling & simulation efforts for infectious disease assets, applying pharmacokinetic and pharmacodynamic principles to support drug development from early stages through registration and lifecycle management. Develop population PK/PD and exposure-response models, guide dose selection, and present evidence to regulatory bodies. Work within cross-functional teams while maintaining hands-on involvement in quantitative analysis and strategic decision-making.

GSK Stevenage, United Kingdom £183,150 – £305,250 pa

Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

Lead translational strategies for oncology and immunology programs by designing in vivo pharmacology and PK/PD studies to validate AI-designed drug candidates. Bridge computational predictions with experimental validation through CRO partnerships and biomarker-driven approaches. Drive preclinical data generation to inform clinical trial design and regulatory filings.

Isomorphic Labs England

Hybrid Permanent

Research Leader / Senior Scientist (Medicinal Drug Design), Cambridge, MA

Lead or contribute to drug discovery projects at the intersection of medicinal chemistry and AI, guiding programs from initiation to candidate selection. Collaborate closely with machine learning scientists to refine AI-driven drug design models and drive innovation in synthetic organic chemistry. Play a key role in shaping next-generation therapeutic development through strategic input, CRO management, and intellectual property generation.

Isomorphic Labs Cambridge, United Kingdom

Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA

Lead or contribute to drug discovery programs using AI-first approaches, integrating computational chemistry with machine learning to design novel therapeutics. Guide project strategy from hit identification through candidate selection, while collaborating closely with ML scientists and cross-functional teams. Help shape and refine AI models for drug design, with opportunities to lead teams and drive innovation in a dynamic, interdisciplinary environment.

Isomorphic Labs Cambridge, United Kingdom

Associate Director, Clinical Supply Chain, Cambridge, MA

This role involves leading end-to-end clinical trial material planning, vendor management, packaging, labeling, inventory management, and global distribution. You will work closely with Clinical Operations and the Clinical Development team to ensure seamless clinical trial execution and compliance with regulatory standards.

Isomorphic Labs Cambridge, United Kingdom

Associate Director, Clinical Program Management, Cambridge, MA

The Clinical Program Manager will lead the transition of internal drug programs from pre-IND stages into clinical trial execution, coordinating cross-functional global teams and managing timelines, budgets, and vendor partnerships. The role leverages AI and emerging technologies to drive efficient clinical development with a focus on high-probability outcomes. It involves strategic oversight of CROs and collaborators while ensuring alignment between clinical objectives and company goals.

Isomorphic Labs England

Hybrid Permanent

Director, Translational Medicine, Oncology, Cambridge, MA

Lead the development and execution of translational medicine strategies for oncology programs, integrating AI-driven insights to inform clinical trial design and biomarker development. Collaborate with cross-functional teams to translate preclinical findings into clinical applications and advance companion diagnostics. Play a key role in shaping the scientific direction of early-stage drug development using cutting-edge methodologies and digital biology approaches.

Isomorphic Labs Cambridge, United Kingdom

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology and modelling & simulation efforts for infectious disease assets, applying pharmacokinetic/pharmacodynamic and exposure-response modelling to inform dose selection, trial design, and regulatory strategy. Work across development phases from early planning to lifecycle management, with a strong emphasis on hands-on quantitative analysis and scientific leadership within a cross-functional environment.

GSK Canterbury, United Kingdom US$183,150 – US$305,250 pa

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology, modeling, and simulation efforts for infectious disease assets, driving dose selection and development strategy through population PK/PD and exposure-response modeling. Serve as a scientific leader within cross-functional teams while remaining hands-on with quantitative analyses. Contribute to regulatory submissions and advance model-informed drug development across the R&D lifecycle.

GSK United States £183,150 – £305,250 pa

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology and modelling & simulation efforts for infectious disease assets, applying quantitative methods to inform dose selection, trial design, and regulatory strategy. Work across development phases from early planning to lifecycle management, using population PK/PD and exposure-response modelling. Operate as a scientific leader within a cross-functional environment while remaining hands-on with data analysis and model development.

GSK

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology modeling and simulation efforts for infectious disease assets, combining hands-on pharmacometric analysis with strategic input across clinical development. Design and interpret studies, develop population PK/PD models, and guide dose selection and regulatory strategies. Work within cross-functional teams to influence development decisions and advance model-informed drug development.

GSK

Director of Clinical Pharmacology Modeling and Simulation

Lead clinical pharmacology and modelling & simulation efforts for infectious disease assets, applying pharmacokinetic/pharmacodynamic and population modelling to inform dose selection, trial design, and regulatory strategy. This senior individual contributor role combines hands-on quantitative analysis with strategic leadership across development phases, from early planning to lifecycle management. Work within a science-driven team to advance model-informed drug development using tools like NONMEM, R, and PBPK, while collaborating with cross-functional partners and supporting regulatory submissions.

GSK US$183,150 – US$305,250 pa