Jobs in Cambridge

Director of Nonclinical Safety, Cambridge, MA

Lead the development and execution of nonclinical safety strategies for small molecule drug candidates in oncology and non-oncology programs, integrating AI-driven predictive models with traditional toxicology. Build and scale the nonclinical safety function within an AI-first drug discovery environment, ensuring high-quality data feedback to refine computational models. Collaborate across preclinical, clinical, and regulatory teams to advance compounds through IND and NDA/MAA-enabling studies.

Isomorphic Labs Cambridge, United Kingdom

Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

This role involves designing and executing biological screening cascades to validate computational predictions in drug discovery. The scientist will lead biophysical, biochemical, and cellular assay development, collaborate with CROs, and bridge AI-driven insights with experimental validation across oncology and immunology programs. Close collaboration with medicinal chemistry, structural biology, and machine learning teams ensures data informs rational drug design.

Isomorphic Labs England

Hybrid Permanent

Medical Director, Oncology Clinical Development - GU

This role involves leading medical oversight and clinical strategy for genitourinary (GU) oncology trials within GSK’s R&D pipeline. The Medical Director provides physician-level expertise in study design, safety monitoring, data interpretation, and regulatory engagement, ensuring patient safety and scientific integrity. They collaborate with cross-functional teams and external experts to advance innovative cancer treatments through clinical development.

GSK £189,750 – £316,250 pa

Medical Director, Oncology Clinical Development - GU

This role involves leading medical strategy and oversight for genitourinary (GU) oncology clinical trials within GSK’s R&D pipeline. The Medical Director provides physician-level expertise in study design, real-time safety monitoring, data interpretation, and regulatory engagement, ensuring patient safety and clinical integrity. They work cross-functionally within a matrix team to advance innovative cancer therapies from development through to regulatory submission and scientific dissemination.

GSK £189,750 – £316,250 pa

Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

Lead translational strategies for oncology and immunology programs by designing in vivo pharmacology and PK/PD studies to validate AI-designed drug candidates. Bridge computational predictions with experimental validation through CRO partnerships and biomarker-driven approaches. Drive preclinical data generation to inform clinical trial design and regulatory filings.

Isomorphic Labs England

Hybrid Permanent

Research Leader / Senior Scientist (Medicinal Drug Design), Cambridge, MA

Lead or contribute to drug discovery projects at the intersection of medicinal chemistry and AI, guiding programs from initiation to candidate selection. Collaborate closely with machine learning scientists to refine AI-driven drug design models and drive innovation in synthetic organic chemistry. Play a key role in shaping next-generation therapeutic development through strategic input, CRO management, and intellectual property generation.

Isomorphic Labs Cambridge, United Kingdom

Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA

Lead or contribute to drug discovery programs using AI-first approaches, integrating computational chemistry with machine learning to design novel therapeutics. Guide project strategy from hit identification through candidate selection, while collaborating closely with ML scientists and cross-functional teams. Help shape and refine AI models for drug design, with opportunities to lead teams and drive innovation in a dynamic, interdisciplinary environment.

Isomorphic Labs Cambridge, United Kingdom

Associate Director, Clinical Program Management, Cambridge, MA

The Clinical Program Manager will lead the transition of internal drug programs from pre-IND stages into clinical trial execution, coordinating cross-functional global teams and managing timelines, budgets, and vendor partnerships. The role leverages AI and emerging technologies to drive efficient clinical development with a focus on high-probability outcomes. It involves strategic oversight of CROs and collaborators while ensuring alignment between clinical objectives and company goals.

Isomorphic Labs England

Hybrid Permanent

Director, Translational Medicine, Oncology, Cambridge, MA

Lead the development and execution of translational medicine strategies for oncology programs, integrating AI-driven insights to inform clinical trial design and biomarker development. Collaborate with cross-functional teams to translate preclinical findings into clinical applications and advance companion diagnostics. Play a key role in shaping the scientific direction of early-stage drug development using cutting-edge methodologies and digital biology approaches.

Isomorphic Labs Cambridge, United Kingdom

Medical Director, Oncology Clinical Development - GU

This role involves providing medical leadership within oncology clinical development for genitourinary (GU) cancers, focusing on study design, medical monitoring, and safety oversight. The physician will interpret clinical and safety data, contribute to regulatory submissions, and engage with investigators and external experts. Working within a cross-functional team, the role ensures patient safety and clinical integrity across trials while supporting GSK’s mission to advance innovative cancer treatments.

GSK

Medical Director, Oncology Clinical Development - GU

This role involves providing medical leadership in oncology clinical development for genitourinary (GU) cancers, with responsibility for medical monitoring, safety oversight, and clinical data interpretation across trials. The Medical Director integrates physician expertise into study design, regulatory interactions, and cross-functional decision-making, working within a global matrix team. The position requires deep oncology knowledge, experience in clinical trial conduct, and strong collaboration with internal teams and external experts.

GSK

Medical Director, Oncology Clinical Development - GU

This role involves providing medical leadership in oncology clinical development, specifically for genitourinary (GU) cancers. The Medical Director will lead medical monitoring, contribute to protocol design, interpret clinical data, and ensure patient safety across clinical trials. They will work closely with cross-functional teams, engage with external experts, and support regulatory submissions and scientific communications within a global pharmaceutical environment.

GSK

Hybrid Permanent

Medical Director, Oncology Clinical Development - Hematology

This role involves leading medical oversight and clinical development for oncology and hematology programs, with responsibilities spanning study design, safety monitoring, data interpretation, and regulatory engagement. The Medical Director will collaborate with cross-functional teams and external experts to ensure clinical integrity and patient-centered decision-making in late-stage drug development. The position requires deep expertise in hematology-oncology and experience in Phase I–III trials within a pharmaceutical or biotech setting.

GSK PLN 455,250 – PLN 758,750 pa

Clinical Development Senior Medical Director - Cardiovascular

Lead clinical development for vascular programs across early and late-phase trials, designing studies and translational plans to advance medicines for cardiovascular disease. Collaborate with cross-functional teams to shape clinical strategies, ensure regulatory compliance, and drive patient-focused innovation within GSK’s R&D pipeline.

GSK

Clinical Development Senior Medical Director - Cardiovascular

Lead clinical development for vascular programmes across early and late phases, designing studies and translational plans to advance medicines for cardiovascular disease. Collaborate with cross-functional teams to shape clinical strategies, ensure patient safety, and drive innovation in drug development. Play a key role in regulatory interactions, trial oversight, and identifying transformative opportunities in vascular medicine.

GSK