Senior individual contributor shaping GSK's Enterprise AI portfolio for technology and R&D portfolio management, from intake and prioritization through funding, resource allocation and benefits tracking. Combines hands-on prototyping of LLM and agentic systems with executive-level business cases, opportunity sizing and operating-model redesign, without managing engineers.
Builds and maintains financial and valuation models (NPV/rNPV, scenario and sensitivity analysis) and portfolio forecasts, metrics and KPI dashboards for R&D investment decisions. Runs probabilistic and Monte Carlo simulations, cleans data from scientific, clinical, financial and operational sources, and prepares decision materials for portfolio reviews. Works with the Head of Data Science and the Finance Portfolio Analytics Manager in a hybrid, high-visibility team.
Designs and delivers immunogenicity and bioanalytical strategies for regulated clinical programmes, developing ADA, nAb, PK and PD assays using ELISA, MSD, cell culture and immunoblotting. Works with preclinical, clinical operations and sample management teams to define sample journeys and expand internal bioanalytical capabilities for the mRNA pipeline.
Perform routine cGMP Quality Control testing using HPLC, UPLC, GC, UV spectroscopy, DLS and Karl Fischer analysis, supporting raw materials, in-process materials, drug substance and product release. Coordinate and execute global GMP stability programs, managing sample lifecycles in LabVantage LIMS, trending data and authoring protocols and regulatory documentation. The role is 100% onsite at Moderna's Harwell mRNA manufacturing facility, working across QC, Manufacturing, QA and external testing partners.
Provides medical and scientific expertise in safety evaluation and risk management for GSK assets across clinical development and post-marketing settings. Leads signal detection, benefit-risk assessment, regulatory periodic reports and RMPs, and contributes to safety strategy within a global cross-functional matrix. Involves presenting complex safety issues to senior governance committees and mentoring matrix colleagues.
Leads the global development of a medicine from clinical Proof of Concept to approval in first major markets, acting as the single point of accountability. Builds and directs a matrixed Medicine Development Team spanning clinical, medical, commercial and manufacturing, and owns the asset budget and resourcing plan. Hybrid role requiring at least two days per week on-site at a US or UK GSK site.
Leads the global development of a medicine from clinical Proof of Concept through first major-market approval, acting as the single point of accountability. Builds and directs a matrixed Medicine Development Team spanning clinical, medical, commercial and manufacturing, and owns the asset's strategy, budget and governance decisions.
Leads the global development of a medicine from clinical Proof of Concept to approval in first major markets, acting as single point of accountability. Builds and directs a matrixed Medicine Development Team spanning clinical, medical, commercial and manufacturing, driving strategy, governance and go/no-go decisions. Hybrid role with at least two days per week on-site.
Leads respiratory epidemiology and real-world evidence programs that inform vaccine development, accountable for at least one asset or disease area and its Global Epidemiology Plan. Designs and oversees complex observational studies using claims, EHR and registry data, advises clinical, safety and regulatory matrix teams, and manages external partnerships and scientific dissemination. Also mentors junior epidemiologists and represents the company with regulators and at international conferences.
Leads respiratory epidemiology and real-world evidence programs that inform vaccine development, designing and overseeing complex studies on disease burden, treatment patterns and safety. Partners across clinical development, safety, regulatory and health outcomes, manages external collaborations, and mentors junior scientists. Hybrid role requiring on-site presence at least two days per week.
Leads respiratory epidemiology and real-world evidence programmes that inform vaccine development, designing and overseeing complex studies on disease burden, treatment patterns and safety. Partners with clinical development, safety, regulatory and external collaborators, and mentors junior staff. Requires deep RWE and pharmaco-epidemiology expertise in a global, matrixed environment.
Leads respiratory epidemiology and real-world evidence programs that inform vaccine development, owning the epidemiology plan for at least one asset or disease area. Designs and oversees complex observational studies using claims, EHR and registry data, advises clinical, safety and regulatory teams, and manages external partnerships while mentoring junior scientists.
Leads quantitative systems pharmacology and QST modelling within a clinical pharmacology and quantitative medicine group, building mechanistic mathematical models of disease and drug action to inform trial design and MIDD strategy. Collaborates with biologists, clinicians, pharmacometricians and AI/ML teams, and represents the function on internal advisory boards.
Leads quantitative systems pharmacology and QST modelling within a clinical pharmacology and quantitative medicine group, building mechanistic models of disease and drug action and running simulations to inform trial design. Defines and coordinates MIDD strategies across respiratory, immunology and inflammation programmes, working with biologists, clinicians, pharmacometricians and AI/ML specialists. The role sits in a newly formed centre of excellence and involves representing QSP on internal advisory boards.
Leads quantitative systems pharmacology and QST modelling within a clinical pharmacology and quantitative medicine group, building mechanistic models of disease and drug action and running simulations to assess trial design. Defines and coordinates MIDD strategies across respiratory, immunology and inflammation programmes, working with biologists, clinicians, pharmacometricians and AI/ML specialists. The role sits in a newly established Centre of Excellence for model-informed drug development.
