Latest Isomorphic Labs Jobs

Research Leader (DMPK), Cambridge, MA

Lead DMPK strategy for drug discovery projects using an AI-first approach, integrating quantitative pharmacology and ADME data to guide candidate selection. Collaborate with chemistry, pharmacology, and machine learning teams to optimise molecule design and advance predictive models. Contribute to regulatory documentation and drive innovation in human PK prediction and biotransformation understanding.

Isomorphic Labs Cambridge, United Kingdom

Research Leader (Toxicology), Cambridge, MA

This role involves leading toxicology strategy in drug discovery with an AI-first approach, designing safety assessment frameworks, and guiding the development of predictive AI models for toxicity. The candidate will work across small molecules and biologics, collaborate with machine learning teams, oversee outsourced wet-lab studies via CROs, and mentor junior scientists. A key focus is reducing reliance on animal testing through innovative, data-driven toxicology solutions.

Isomorphic Labs Cambridge, United Kingdom

Research Leader / Senior Scientist (Medicinal Drug Design), Cambridge, MA

Lead or contribute to drug discovery projects at the intersection of medicinal chemistry and AI, guiding programs from initiation to candidate selection. Collaborate closely with machine learning scientists to refine AI-driven drug design models and drive innovation in synthetic organic chemistry. Play a key role in shaping next-generation therapeutic development through strategic input, CRO management, and intellectual property generation.

Isomorphic Labs Cambridge, United Kingdom

Research Engineer (LLM Performance), London

You will work on optimizing large language models for performance and scalability within a cutting-edge AI-driven drug discovery environment. The role involves implementing post-training methods, diagnosing distributed system bottlenecks, and deploying low-precision techniques to support real-world drug design applications. Collaboration with interdisciplinary research teams is central to translating novel AI methods into production-ready systems.

Isomorphic Labs London, United Kingdom

Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA

Lead or contribute to drug discovery programs using AI-first approaches, integrating computational chemistry with machine learning to design novel therapeutics. Guide project strategy from hit identification through candidate selection, while collaborating closely with ML scientists and cross-functional teams. Help shape and refine AI models for drug design, with opportunities to lead teams and drive innovation in a dynamic, interdisciplinary environment.

Isomorphic Labs Cambridge, United Kingdom

Senior Clinical Trial Manager, Cambridge, MA

The role involves end-to-end management of clinical trials within a fast-paced, AI-driven drug discovery environment. The Senior Clinical Trial Manager will lead cross-functional teams, oversee trial start-up through close-out, ensure compliance with ICH/GCP standards, and integrate AI innovations into clinical operations. Key responsibilities include vendor and budget management, clinical documentation, data oversight, and supporting regulatory readiness and audits.

Isomorphic Labs Cambridge, United Kingdom

Hybrid Permanent

Team Coordinator, President Team, London

The Team Coordinator supports the President Team by ensuring seamless day-to-day operations, executive meeting readiness, and high-quality guest experiences. This role handles physical logistics for events, internal speaking engagements, and offsites, acting as the on-the-ground point of contact for high-profile visitors and external facilitators. The position requires meticulous attention to detail, proactive problem-solving, and close coordination with internal and external stakeholders to maintain flawless executive suite operations.

Isomorphic Labs London, United Kingdom

Hybrid Permanent

Head of Medicinal Chemistry, Drug Design, London

Lead and strategically guide a team of 25 medicinal chemists in redefining drug discovery through deep integration with AI and machine learning. Shape the scientific direction of projects from hit identification to candidate nomination, while fostering collaboration across computational design, biology, and pre-clinical development teams. Drive innovation by challenging traditional paradigms and embedding an AI-first culture across the chemistry function.

Isomorphic Labs London, United Kingdom

On-site Permanent

ML Research Engineer, London

Develop and optimise cutting-edge AI models at the intersection of machine learning and drug discovery, translating research into scalable, production-ready systems. Work on foundational models like Diffusion networks, Transformers, and GNNs, building robust infrastructure and data pipelines while collaborating closely with scientists. Focus on advancing a digital biology platform to accelerate rational drug design across multiple therapeutic areas.

Isomorphic Labs London, United Kingdom

On-site Permanent

Research Scientist (Applied LLMs), London

A Research Scientist focused on applying Large Language Models to drug discovery, working in interdisciplinary teams to develop novel AI-driven approaches for biological and chemical challenges. The role involves advancing LLM techniques such as post-training, reasoning, tool-use, and alignment within a cutting-edge AI research environment. Collaboration with scientists and engineers is central to developing predictive models that accelerate rational drug design.

Isomorphic Labs London, United Kingdom

Hybrid Permanent

Research Scientist (Machine Learning), London

A Research Scientist in Machine Learning will develop novel deep learning models and algorithms to advance drug discovery at digital speed. Working in an interdisciplinary environment, they will apply cutting-edge ML techniques to complex biological and chemical problems, iterating closely with domain experts. The role involves leading high-ambition research projects, scaling training frameworks, and shaping the technical direction of AI-driven drug design.

Isomorphic Labs London, United Kingdom

Hybrid Permanent

Staff Software Engineer (Inference Platform), London

This role involves leading the reliability and scalability of AI/ML infrastructure for biotech applications, focusing on GPU/TPU systems, workload orchestration, and inference services. The engineer will overhaul monitoring, improve CI/CD stability, and ensure robust platform performance to support cutting-edge drug discovery research. Close collaboration with research and applied ML teams is central to the role.

Isomorphic Labs London, United Kingdom

On-site Permanent

Bioanalytical Lead, London

Lead the development and execution of bioanalytical strategies for a diverse portfolio of AI-designed therapeutics, including small molecules, biologics, and ADCs. Design and validate PK, PD, and immunogenicity assays, manage global CROs, and integrate bioanalytical data into AI models to refine drug discovery. Play a key role in IND-enabling studies and cross-functional preclinical development in a hybrid London-based role.

Isomorphic Labs London, United Kingdom

Hybrid Permanent

Associate Director, Clinical Supply Chain, Cambridge, MA

This role involves leading end-to-end clinical trial material planning, vendor management, packaging, labeling, inventory management, and global distribution. You will work closely with Clinical Operations and the Clinical Development team to ensure seamless clinical trial execution and compliance with regulatory standards.

Isomorphic Labs Cambridge, United Kingdom

Director of Clinical Pharmacology, Cambridge, MA

Lead clinical pharmacology strategy for small molecule programs in oncology and non-oncology areas, designing and executing studies from Phase 1 through late development. Utilize AI-driven models for PK/PD prediction, dose optimization, and regulatory submissions, while managing CROs and translating preclinical data into human dosing strategies.

Isomorphic Labs Cambridge, United Kingdom