Provides advanced scientific expertise in safety evaluation and risk management for key oncology assets in clinical development, leading signal detection, benefit-risk assessment and regulatory safety submissions. Represents SERM on cross-functional clinical matrix teams, escalates emerging safety issues to governance bodies and mentors junior staff within a global matrix environment.
Leads the design and execution of clinical biomarker and translational medicine strategies for late-stage oncology assets, defining predictive biomarkers, patient segmentation and go/no-go decision criteria. Represents Translational Medicine on Clinical Matrix Teams and works across diagnostics, data sciences and external partners to validate assays and deliver biomarker data packages.
You will design and develop LLM applications for drug discovery, working with research scientists and engineers on model architectures, post-training, reasoning, agents and reinforcement learning. The role spans core ML research, scaling training and inference frameworks, and potentially leading standalone projects with technical mentorship.
Builds greenfield machine learning models and algorithms for drug discovery, designing new architectures, running experiments and scaling training and inference frameworks. Works in an interdisciplinary team of ML scientists and domain experts, with opportunities to lead projects and mentor others depending on experience.
Lead clinical pharmacology and pharmacometrics strategy across a portfolio of rare disease and oncology programs, serving as the clinical pharmacology lead and regulatory representative. Oversee modeling and simulation (population PK, PK-PD, exposure-response) and provide pharmacology input on Phase 1-3 study designs. Work cross-functionally with clinical, translational and discovery teams in an end-to-end drug development environment.
Leads the global evidence generation strategy for a rare disease therapy, overseeing HEOR studies such as network meta-analyses, economic models, and non-interventional research from concept to publication. Partners with cross-functional teams and country affiliates to develop value dossiers and patient-reported outcome strategies that support reimbursement and market access. The role sits within Pfizer's HV&E team and involves managing external research collaborations and vendor relationships.
Leads the success of assigned Functional Service Provider clinical operations programs, covering service delivery, financial performance, resource optimization and regulatory compliance. Provides strategic direction to FSP management teams, builds scalable delivery frameworks and performance metrics, and partners with functional and regional leaders to expand service offerings and grow client relationships.
Serves as subject matter expert in COA endpoint strategy, instrument development and regulatory strategy, advising pharma and biotech sponsors and representing the company as an external scientific thought leader. Leads qualitative research supporting content validity, oversees internal project teams, mentors consultants and supports business development through proposals and client presentations.
Supports clinical trial site management remotely, liaising with CRAs and study teams on site preparedness, document collection, vendor trackers and remote monitoring tasks. Handles essential documents, site payments, reconciliations and centralized monitoring reviews in line with SOPs and ICH GCP. Suits an early-career life sciences graduate seeking a UK-based remote clinical research role.
Provides clinical and scientific leadership across early and late-stage respiratory programs, designing clinical development plans, protocols and regulatory documents while overseeing medical monitoring and participant safety. Leads a cross-functional Clinical Matrix Team, shaping translational strategy, target validation and evidence generation in partnership with biology, regulatory and commercial groups.
