Provides advanced scientific expertise in safety evaluation and risk management for key oncology assets in clinical development, leading signal detection, benefit-risk assessment and regulatory safety submissions. Represents SERM on cross-functional clinical matrix teams, escalates emerging safety issues to governance bodies and mentors junior staff within a global matrix environment.
Provides advanced scientific expertise in safety evaluation and risk management for key oncology assets in clinical development, leading signal detection, benefit-risk assessment and regulatory safety submissions. Represents SERM on cross-functional clinical matrix teams, escalates emerging safety issues to governance bodies and mentors junior staff within a global matrix.
Research engineers translate frontier research concepts into practical implementations, building and optimising state-of-the-art AI models such as Transformers, GNNs and diffusion models, plus the codebases, data pipelines and infrastructure for training and evaluation. The role sits in an interdisciplinary team of drug discovery experts and ML specialists, with a strong emphasis on experimentation, benchmarking and taking models from conception to production.
Lead and execute the translational medicine strategy for an oncology portfolio, ensuring clinical biomarker assay readiness and data delivery to inform mechanism of action, resistance and future indications. Serve as a core program team member and cancer biology expert, collaborating with AI and computational biology teams to build innovative biomarker analysis tools and advance companion diagnostics.
Senior physician role providing metabolic therapeutic and drug-development expertise to a clinical research organisation, supporting major proposals and bid defences, client peer-to-peer engagement, and protocol design. Also trains and mentors internal clinical teams, authors regulatory documents, and liaises with investigators and KOLs. Requires an MD with metabolic subspecialty certification and fluency in English and Mandarin, with travel to China.
Senior physician role leading medical science and strategy for oncology across a clinical research business, shaping RFP responses, bid defences and protocol design while engaging client medical leadership. Also provides therapeutic training, mentoring and regulatory document input, working in a matrixed global team with international travel.
This role involves leading the R&D Resource and Schedule Management capabilities, defining the mission, governance, and operating model. Responsibilities include capacity and demand management, scenario planning, and stakeholder engagement to ensure alignment with organizational goals and portfolio priorities.
Lead clinical pharmacology and pharmacometrics strategy across a portfolio of rare disease and oncology programs, serving as the clinical pharmacology lead for regulatory interactions and study design from Phase 1-3. Perform and oversee modeling and simulation with tools such as WinNonlin, Monolix, NONMEM and R, and author regulatory sections for IBs, INDs and NDAs. Part of a Pharmacometrics team spanning clinical pharmacology, pharmacometrics and translational modeling, working end-to-end across discovery and development.
Develop, optimize and validate cell-based and biochemical assays for automated high-throughput screening, running workflows at scale across 384- and 1536-well formats. Work in a cross-disciplinary team with biologists, automation and data scientists, documenting methods so assays transfer reliably. A 9-month contractor role, Monday to Friday, 9am-5pm.
Field-based commercial role owning relationships with Advanced Therapy Treatment Centres across the South UK, acting as the primary point of contact for CAR T therapy accounts. Responsibilities span site onboarding and qualification, coordinating patient treatment logistics and chain of identity, compliance audits, and strategic account planning with Marketing, Medical Affairs and Market Access. Requires deep haematology/oncology and cell therapy expertise, with around 80% travel.
Leads global health economics and outcomes research for a rare disease asset, developing evidence generation strategy and HEOR studies such as network meta-analyses, economic models and patient-reported outcomes. Oversees launch deliverables including value dossiers and systematic literature reviews, working with cross-functional and country teams to support reimbursement and patient access.
Primary point of contact for Advanced Therapy Treatment Centres in the South UK, driving appropriate utilisation of CAR T therapies and coordinating site qualification, setup and patient treatment logistics. Works cross-functionally with Marketing, Medical Affairs and Market Access, and is 80% field based with UK travel.
Leads global evidence generation and health economics and outcomes research for a rare disease therapy, designing HEOR studies, economic models and value dossiers to support reimbursement and patient access. Works within a cross-functional matrix team and with country teams, guiding clinical trial design and payer-facing evidence strategy.
Independent clinical quality-risk leadership role translating risk signals into proactive mitigation, escalation and inspection readiness across trials and programs. Involves maintaining Clinical Quality Plans, driving risk monitoring reviews, advising on CAPA plans, and leading pre-submission quality portfolio reviews and mock inspections. Combines hands-on risk ownership with cross-functional influence and coaching of team members.
Owns International regulatory strategy for complex cell therapy programmes, embedding regional requirements into evidence generation, submission strategy and labelling from development through launch and life-cycle management. Orchestrates Health Authority engagements, dossier and labelling negotiations, and leads a matrix International Regulatory Team while partnering with Global, Area, Commercial and Medical colleagues.
